Virtual Conference

Mahmoud Bader

King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia

Title: Association Between COVID-19 Infection and Cardiac Biomarkers in Hospitalized Patients at a Tertiary Care Center


Objective: The effects of coronavirus disease 2019 (COVID-19) on the cardiovascular system are well established. However, knowledge gaps in the clinical implications of cardiac involvement in COVID-19 patients are yet to be addressed. This study aimed to investigate acute cardiac injury (ACI) risk factors and outcomes associated with COVID-19 infection with cardiac involvement.
Method: In this study, we included hospitalized patients between March 2020 and May 2022 with confirmed COVID- 19 infection and evidence of cardiac involvement.
Results: In total, 501 patients were included, of whom 396 (79%) had evidence of ACI. The median troponin level was 25.8 (interquartile range [IQR]: 10.8-71). Patients with evidence of ACI were significantly more likely to have diabetes mellitus (75% vs. 60%), cardiovascular disease (48% vs. 37%), chronic lung disease (22.2% vs. 12.4%), and chronic kidney disease (32.3% vs. 16.2%). Additionally, patients with ACI were significantly more likely to have cardiomegaly (60.6% vs. 44.8%) and bilateral lobe infiltrates (77.8% vs. 60%) on X-ray. Patients with ACI were significantly more likely to suffer from complications such as cardiogenic shock (5.3% vs. 0%), pneumonia (80.1% vs. 65.7%), sepsis (24.2% vs. 9.5%), and acute respiratory distress syndrome (33.1% vs. 8.6%). Patients with ACI were also significantly more likely to be admitted to the intensive care unit (ICU) (57% vs. 26.7%) and significantly more likely to die (38.1% vs. 11.4%). The results of the multivariate regression analysis indicate that mortality was significantly higher in patients with elevated troponin levels (adjusted odds ratio [OR]: 4.73; 95% confidence interval [CI]: 2.49-8.98).
Conclusion: In COVID-19 patients who exhibited cardiac injury, age, diabetes mellitus, chronic lung disease, and chronic kidney disease were associated with increased risk of ACI. Patients with these risk factors are at risk of severe complications, such as ICU admission, sepsis, and death.


Mahmoud Bader is a 4th year medical student at King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. Mahmoud has a strong interest in cardiology and cardiothoracic surgery. He is working on multiple research projects on topics ranging from cardiology, infectious disease, psychiatry, neurology, and general surgery.