Introduction: Coronary artery disease in octogenarians poses more comorbidities and complicated angiographic lesions for the diagnostic and therapeutic approach. Percutaneous coronary intervention has been shown to be a safe and beneficial method of revascularization, it increases quality of life, and it reduces mortality.

Objective: To characterize the immediate results of percutaneous coronary intervention in octogenarian patients.

Methods: An observational, analytical, cross-sectional study was carried out in 115 octogenarians who underwent percutaneous coronary intervention at the Institute of Cardiology and Cardiovascular Surgery in Havana, Cuba, from January 2016 to December 2020. The sociodemographic, clinical, and angiographic variables were studied, as well as the main complications.

Results: The mean age was (83.4 ± 3.6), 62.6% male. Acute coronary syndrome was the most common diagnosis. Primary angioplasty was the most frequent emergency procedure; 40% had multiverse coronary artery disease and the anterior descending artery was the diseased vessel, with reduced number of complications.