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Joseph Ainé Umugwaneza
Geriatric Public Hospital: EHPAD Jouarre, FrancePresentation Title:
Matrix metalloproteinase type 9 activity and its association with thoracic aortic calcification in patients with resistant hypertension: A comparative cross-sectional study
Abstract
Resistant hypertension (RH) is characterized by severe endothelial dysfunction (ED) and extracellular matrix (ECM) changes. This may be regulated by the activity of matrix metalloproteinases (MMPs).
Purpose: To study the level of MMP type 9, TIMP-1in patients with RH.
Methods: In total 138 patients with RH were recruited (61 men, age 65.3 ± 7.1). Patients were divided into 2 groups: 1- uncontrolled (UCRHTN, n = 70) and 2-controlled (CRHTN, n = 68) resistant hypertension. An ABPM and reactive hyperemia test were performed. MMP-9 and TIMP-1 levels were determined using an enzyme-linked immunosorbent assay.
Results: In the 2nd group, a higher pulse pressure was observed (52.5 [47.0; 56.5] mm Hg and 60.0 [55.0; 65.0] mm Hg; p<0.0001), morning rise in pressure (20.5 [19.0; 23.5] mm Hg and 28.0 [23.0; 32.0] mm Hg; p<0.0001), daily systolic pressure index (8.5 [6; 11] % and 6.5 [3; 8] %, p=0.0013). The increase in the diameter of the PA in the 1st group was 9.2 [7.89; 11.22] %, in the 2nd group 9.0 [6.88; 10.60] %, (p = 0.070), but the maximum diameter in the 1st group was recorded at the 60th second, in the 2nd - at the 90th second (p = 0.0032). MMP-9 was high and did not differ between groups (233.5 [179.5; 280.0] ng/ml and 238.0 [184.0; 306.0] ng/ml, p=0.467. In the 2nd group, TIMP-1 was higher (439.5 [348.5; 565.0] ng/ml and 561.0 [469.0; 730.0] ng/ml, p=0.000302) and the TIMP-1/MMP-9 ratio (1.95 [1.70; 2.20] and 2.40 [2.10; 2.90], p=0.000009). In the second group, the TIMP-1/MMP-9 ratio correlated with PBP (r = 0.31, p = 0.0097), morning rise in BP (r = 0.57, p <0.00001) and daytime SBP variability (r = 0.46, p <0.0001). A strong negative association between MMP-9 and PA diameter was found after decompression.
Conclusion: This study confirms the association of RG, MMP and TIMP1 with endothelial function and BP regulation.
Biography
Joseph Ainé Umugwaneza is a researcher and clinician at the Geriatric Public Hospital: EHPAD Jouarre, France. His work focuses on cardiovascular health in elderly populations, with particular expertise in resistant hypertension, endothelial dysfunction, and extracellular matrix remodeling. He has contributed to studies investigating the role of matrix metalloproteinases and their inhibitors in vascular pathology.
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