Mekhman N Mamedov
National Research Center for Therapy and Preventive Medicine, RussiaPresentation Title:
Risk factors and prevention of cardiovascular complications in breast cancer
Abstract
Breast cancer (BC) is the most common malignant tumor in women. At an early stage, in patients who have undergone antitumor treatment at an early stage of BC, death in the long term occurs more often from cardiovascular diseases (CVD) than from oncopoptosis.
Numerous studies indicate that the risk of cardiomyopathy and/or heart failure, coronary heart disease among survivors of BC treatment who received anthracyclines and/or trastuzumab increases. Currently, early detection of cardiotoxicity using cardiac imaging and circulating cardiovascular biomarkers is widely evaluated in clinical trials.
On the other hand, the high CVD risk observed in cured breast cancer survivors is a consequence of both the adverse effects of cancer therapy on the cardiovascular system, including antiestrogens, and the presence of common cancer and CVD risk factors.
Large clinical trials have reported higher rates of hypertension, hypercholesterolemia, and ischemic CVD in postmenopausal breast cancer survivors receiving aromatase inhibitors.
Strategies for the prevention and treatment of left ventricular dysfunction or heart failure associated with treatment in patients with breast cancer should include a comprehensive assessment of cardiovascular risk and individual clinical assessment.
Biography
Dr. Mamedov was born on January 10, 1970, in Sheki, Azerbaijan, and is a distinguished Azerbaijani cardiologist based in Moscow, Russia. He completed his medical education at the Moscow Medical Academy named after I.M. Sechenov, followed by postgraduate and doctoral studies in cardiology at the National Research Center for Preventive Medicine. Since 2002, Dr. Mamedov has led the Department of Secondary Prevention of Chronic Non-infectious Diseases at the National Research Center for Therapy and Preventive Medicine. His research focuses on cardiovascular disease epidemiology, risk factors, and pharmacotherapy. Dr. Mamedov has authored 468 articles, 13 monographs, and holds a Hirsch index of 40. He serves as the President of the Cardioprogress Foundation, is on the board of the Russian Society of Cardiology, and is Editor-in-Chief of the International Journal of Heart and Vascular Diseases.
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